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副教授

裴晓静

裴晓静,博士,副教授,硕士生导师

联系方式:pxj@btbu.edu.cn

通讯地址:北京市海淀区阜成路11

教育及工作经历:

2020.10-至今,北京工商大学轻工科学与工程学院,副教授。

2019.07-2020.10,北京工商大学理学院化学系,讲师。

2014.09-2019.07,北京大学,分析化学专业,获理学博士学位。

2010.09-2014.07,山东师范大学,应用化学专业,获理学学士学位。

研究领域:

1. 核酸相关化妆品研发及转化;

2. PDRN微球化研究及转化;

3. 化妆品创新剂型研究及转化;

4. 生化分析及生物传感。

5. 数字化CRISPR/Cas探针构建及应用;

教学工作:

本科:《分析化学》、《大学化学》、《实验安全教育》

研究生:《实验数据处理及信息化技术》、《分子光谱分析》

主持科研项目:

(一)主持国家自然科学基金青年项目,220040052021.01-2023.12

(二)主持北京市教委一般项目,KM2021100110112021.01-2023.12

(三)主持新冠病毒检测项目,20223812022.10-2023.10

(四)主持北京工商大学青年启动基金,QNJJ2020-032019.10-2020.12

(五)茉颜个性化服务化妆品项目,2024.05-2025.05

(六)靶向制剂产业化合作,2024.06-2025.07

通讯及一作研究论文:

1. Liu, Y.; Hu, W.; Pei, X.*; Zhu, J.; Meng, H.; Lyu, Y.; Qu, Z., Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy. International Journal of Biological Macromolecules 2025, 322, 146984.

2. Xu, L., Liu, S., Huang, Z.Pei, X.*. CRISPR-Cas12a Coupled with Universal Dual-mode Fluorescent Nanoparticles Platform for HPV Nucleic Acid Detection. J. Anal. Test. 2025,9, 153–159.

3. Xu, L.; Shang, Z.; Liu, D.; Zhao, C.; Zhao, C.; Pei, X.*; Zhang, Z., Preparation, characterization and efficacy of hyaluronic acid-modified two targeted liposomes for ectoin delivery to the skin. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2025, 719, 137013.

4. Li, J.; He, H.; Zhu, J.; Li, S.; He, Y.; Zhang, Z.; Pei, X.*, Preparation of hydroxypinacolone retinoate nanoemulsion with high stability, low irritation and high permeability. Journal of Drug Delivery Science and Technology 2025, 107, 106822.

5. Shang, ZL; Liu, ST; Liu, DX; Wang, Y; Pei, X*; Li, SJ; He, YF; Tong, YG; Systematically Investigating CRISPR/Cas12a Fluorescent Biosensor for Sensitive and Specific Single Nucleotide Variants Detection. Journal of Fluorescence. DOI:10.1007/s10895-025-04360-5.

6. Liu, D.; Hu, W.; Shang, Z.; Pei, X.*; Sun, J.; Zhou, L.; He, Y.; Li, S.; Qu, Z.; Zhang, Z., Preparation and Characterization of a Novel Cooling Agent with Intelligent Response Long-Term Release Effect. Journal of Applied Polymer Science 2025, 142 (16).

7. Meng H., Xiong J., Hu W., Huang Z., Pei, X.* Flexible Nanoliposomes of Pterostilbene for Local Delivery: Potential for Increasing Skin Elasticity and Brightening Skin Effects. Current Pharmaceutical Biotechnology 2025.

8. He. Y.; Huang Z.; Yang X.; Dong Y; Pei X.*Advances on the mechanism and applications of stimulus-responsive DNA hydrogels Current Pharmaceutical Biotechnology 2025.

9. He H.; Pei X*; Zhang Z. Li S.;He Y.; Meng H. *, Yinmao Dong Preparation and Characterization of PDRN-Modified Ceramide Cationic Nanoemulsion (PDRN-CER-CNE) for Anti-Photoaging Cosmetics" poster at the 35th IFSCC Congress 2025.

10. Wang Y., Peng Y., Liu S., Li M., Pei X* CRISPR/Cas12a coupled with loop-mediated isothermal amplification and lateral flow assay for SARS-CoV-2 detection Anal. Methods, 2024, 16, 5971.

11. Li, S.; Shi, W.; Wang, X.; Li, S.; Pei, X.*; He, Y., Electrospinning of gelatin nanofibers containing sesamol nanoparticles. Journal of the Textile Institute 2024, 115 (5), 844-852.

12. Xu, L.; Huang, Z.; Pei, X.*; Zhang, Z.; Li, S.; He, Y., Preparation and Characterization of Universal Liquid Proliposomes Encapsulating Water-soluble Efficacious Substances. Current Pharmaceutical Biotechnology 2024.

13. Shang, Z.; Liu, S.; Liu, D.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G., CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection. Molecules 2024, 29 (24).

14. Liu, S.; Huang, Z.; Luo, M.; Wang, Z.; Chen, H.; Zhang, Y.; Pei, X*, The Signal -Sensing Techniques and Recent Applications of CRISPR-Cas System. Spectroscopy and Spectral Analysis 2024, 44 (4), 918-924.

15. Liu, S.; Xu, L.; Huang, Z.; Zhang, Y.; Pei, X.*; Li, S.; He, Y., Recent advances of nanoparticles-assisted CRISPR/Cas biosensors. Microchemical Journal 2024, 199.

16. Huang, Z.; Meng, H.; Xu, L.; Pei, X.*; Xiong, J.; Wang, Y.; Zhan, X.; Li, S.; He, Y., Liposomes in the cosmetics: present and outlook. Journal of Liposome Research 2024, 34 (4), 715-727.

17. Deng, Y.; Zhang, Z.; Zhou, Y.; Pei, X.*; He, Y.; Wu, T., Introducing uracil-containing oligo to improve exponential amplification reaction performance in biosensor application. Microchemical Journal 2023, 191.

18. Liu, S.; Xie, T.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. CRISPR-Cas12a coupled with universal gold nanoparticle strand-displacement probe for rapid and sensitive visual SARS-CoV-2 detection Sensors and Actuators B-Chemical 2023, 377, 133009.

19. Liu, S.; Xie, T.; Huang, Z.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. Systematically investigating the fluorescent signal readout of CRISPR-Cas12a for highly sensitive SARS-CoV-2 detection. Sensors and Actuators B-Chemical 2022, 373, 132746.

20. Huang, Z.; Liu, S.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. Fluorescence Signal-Readout of CRISPR/Cas Biosensors for Nucleic Acid Detection. Biosensors 2022, 12, 779.

21. Pei, X.; Hong H, Liu S. and Li N., Nucleic Acids Detection for Mycobacterium tuberculosis Based on Gold Nanoparticles Counting and Rolling-Circle Amplification Biosensors 2022, 12, 448.

22. Pei, X.; Lai, T.; Tao, G.; Hong, H.; Liu, F.; Li, N. Ultra-specific multiplexed detection of low-abundance single-nucleotide variants by combining masking tactic with fluorescent nanoparticle counting. Anal. Chem. 2018, 90, 4226−4233.

23. Pei, X.; Yin, H.; Lai, T.; Zhang, J.; Liu, F.; Xu, X.; Li, N. Multiplexed detection of attomoles of nucleic acids using fluorescent nanoparticle counting platform. Anal. Chem. 2018, 90, 1376−1383.

24. Pei X.; Wu X.; Xiong J.; Wang G.; Tao G.; Ma Y.; Li N.; Competitive aptasensor for the ultrasensitive multiplexed detection of cancer biomarkers by fluorescent nanoparticle counting Analyst, 2020, 145, 3612−3619.

25. Pei X.; Tao G.; Wu X.; Ma Y.; Li. R; Li N.; Nanomaterial-based multiplex optical sensors Analyst, 2020, 145, 4111–4123

26. Pei, X.; Huang, H.; Chen Y; Li C.; Liu, F.; Li, N. Modulating fluorescence anisotropy of dye-labeled DNA without involving mass amplification. Talanta 2016, 154, 567−573.

27. 张钰婕,刘思彤,徐龙飞,裴晓静* 诗情——诗词中的化学;Univ. Chem. 2023, 38, 1−5

28. 詹鑫,刘宇欣,裴晓静*,祝钧,李姝静,何一凡,徐帆,李佳宇,复乳法制备二氢杨梅素脂质体。香料香精化妆品

29. 赵成可,刘东旭,赵彩云,尚振林,裴晓静*,李姝静,何一凡,大马哈鱼提取物化妆品应用分析综述。香料香精化妆品

30. 张钰婕,于晨旭,张沛敏,裴晓静*等。虾青素脂质体的制备及其应用研究[J].广东化工202350(19):45-47.

31. 参编出版著作《CRISPR分子诊断技术原理及应用》人民卫生出版社2025

获奖情况:

1. 2024 北京工商大学优秀班主任;

2. 2022 北京工商大学优秀班主任;

3. 2020 北京分析测试科技成果及青年人才成长评价优秀论文二等奖;

4. 2020 主讲《分子光谱分析》获北京工商大学优秀课程思政建设课程;

5. 2020 北京工商大学课程思政优秀教师三等奖;

6. 2018 北京大学博士生国家奖学金;

7. 2018 全国光谱大会青年论坛一等奖;

8. 2018 获北京大学学术创新奖;

9. 2018 获北京大学优秀科研奖;

    10. 2016 获北京大学化学与分子工程学院孙亦樑分析化学奖。